A Morita–Baylis–Hillman adduct allows the diastereoselective synthesis of styryl lactones
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چکیده
منابع مشابه
Organocatalytic enantio- and diastereoselective synthesis of highly substituted δ-lactones via a Michael-cyclization cascade.
An organocatalyzed Michael-cyclization cascade approach of readily available α,β-unsaturated aldehydes and pyrazoleamides has been developed to get highly substituted δ-lactones in excellent enantioselectivities (up to 97%) and diastereoselectivities. The δ-lactones so obtained could easily be transformed into benzazepine derivatives with excellent enantio- and diastereoselectivities. Furthermo...
متن کاملcomparison of catalytic activity of heteropoly compounds in the synthesis of bis(indolyl)alkanes.
heteropoly acids (hpa) and their salts have advantages as catalysts which make them both economically and environmentally attractive, strong br?nsted acidity, exhibiting fast reversible multi-electron redox transformations under rather mild conditions, very high solubility in polar solvents, fairly high thermal stability in the solid states, and efficient oxidizing ability, so that they are imp...
15 صفحه اولLactones 5 * . Synthesis of Some Terpenoid Lactones from , - Epoxy Esters
Synthesis of bicyclic [1] and tricyclic [2] terpenoid lactones and the preliminary results of biological tests for their feeding deterrent activity [3] previously were presented. The tests, which were carried out on three storage pest insects: the grain weevil (Sitophilus granarius L.), the confused flour beetle (Tribolium confusum Duv.) and the khapra beetle (Trogoderma granarium Ev.), showed ...
متن کاملDiastereoselective Total Synthesis of (-)-Galiellalactone.
An enantioselective total synthesis of (-)-galiellalactone has been accomplished. The key features of the synthesis involve the highly stereoselective construction of the cis-trisubstituted cyclopentane intermediate by a Pd(0)-catalyzed cyclization, the stereospecific introduction of an angular hydroxyl group by Riley oxidation, and the efficient construction of the tricyclic system of (-)-gali...
متن کاملHighly diastereoselective synthesis of spiropyrazolones.
We report a highly diastereoselective synthesis of spiropyrazolones catalyzed by secondary amines. The reported Michael-Aldol cascade reaction affords the desired spiropyrazolones bearing four chiral centers as a single diastereomer in excellent yields.
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ژورنال
عنوان ژورنال: Tetrahedron Letters
سال: 2011
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2011.09.044